Define dendrite pruning2/17/2024 These are found to be dependent on both, internal as well as external cues ( Parrish et al., 2007 Jan and Jan, 2010). An intrinsic genetic program patterns the arbors using molecular processes that are distinct from those that make axons. The dendritic tree structure is unique to a given neuronal cell type and plays a fundamental role in establishing specific neuronal connectivity. During neuronal development, morphogenetic processes that are not yet completely understood, lead to formation of arbors with defined size, geometry, innervation, and tiling patterns. An understanding of regulatory elements, such as Mon1, as demonstrated in our study, is essential to understand neuronal function.ĭendritic arbors are complex neuronal structures with distinct morphological features ( Cajal, 1999 Garcia-Lopez et al., 2010 Berry and Nedivi, 2017). Dendritic branching is critical for proper connectivity and physiological function of the neuron. We have conducted genetic epistasis experiments, by modulating the activity of Rab5, Rab7, and Rab11 in da neurons, in Mon1 mutants, and demonstrate that the ability of Mon1 to regulate arborization is possibly due to its effect on the recycling pathway. Earlier, these GTPases, specifically Rab1, Rab5, Rab10, and Rab11 have been shown to regulate dendritic arborization. The ability of Mon1 to influence dendritic development is possibly a function of its interactions with Rab family GTPases that are central players in vesicular trafficking. Loss of Mon1 function leads to an increase in arborization and complexity, while increased expression, leads to reduced arborization. We find that Mon1 activity modulates the complexity of Class IV dendritic arborization (da) neurons during larval development. Monensin Sensitive 1 (Mon1) is a component of the Mon1:Ccz1 complex that mediates Rab5 to Rab7 conversion in eukaryotic cells by serving as a guanine nucleotide exchange factor for Rab7 during vesicular trafficking. 2Agharkar Research Institute, Pune, India.1Indian Institutes of Science Education and Research, Pune, India.Rohit Krishnan Harish 1†‡ Shweta Tendulkar 1‡ Senthilkumar Deivasigamani 1*† Anuradha Ratnaparkhi 2* Girish S.
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